The Power of Spatial Biology

Vicinity Bio Tübingen GmbH

Promoting Spatial Biology Discovery – from Sample 2 Answer

At Vicinity Bio, we provide cutting-edge services for generation, management analysis and interpretation of ultra-high plex tissue imaging data.

Research

Understanding the complexity of tissue composition and the individual cellular interactions is key to interfere successfully in non-physiologically conditions. Vicinity Bio supports in basic and translational research questions at individual levels.

Patient Support

Tumors are composed of shared and unique features and often very adaptive. This is why fighting cancer is so difficult. Vicinity Bio supports clinicians in their decision finding process for individualized therapy selections with pathologic reports.

Technology

Vicinity Bio combines ultra-high plex tissue imaging technologies with cutting-edge machine learning and AI supported bioinformatic pipelines for the generation of comprehensive interpretation of proteOMICs data.

Product lines

Sample 2 Clinical Decision Support

The generated high-dimensional proteOMICs data are examined and evaluated jointly by pathologists and bioinformatics. It results in a comprehensive pathological report that describes the expression of biomarkers (for example the presence and amount of certain tumor or immune cells that are positive) and contains a non-binding recommendation as to which biomarkers could be suitable for a individual therapy.

Sample 2 Discovery

Vicinity Bio allows customers to generate ultra-high-plex tissue imaging data and perform standardized bioinformatics analyses on tissue samples to molecularly characterize individual cells, define cell types, and quantify their distribution in the tissue.

About Us

Vicinity Bio's vision is to make spatial biology, and with it its medical and scientific benefits, accessible to everyone. Experts from various disciplines have come together to make this possible.

Picture of PD Dr. Kilian Wistuba-Hamprecht (PhD)

PD Dr. Kilian Wistuba-Hamprecht (PhD)

CEO, Co-Founder

Picture of Prof. Dr. Manfred Claassen (PhD)

Prof. Dr. Manfred Claassen (PhD)

Co-Founder

Picture of Prof. Dr. Dr. Christian Schürch (MD, PhD)

Prof. Dr. Dr. Christian Schürch (MD, PhD)

CMO, Co-Founder

Picture of Dr. Aaron Mayer (PhD)

Dr. Aaron Mayer (PhD)

Non-operational Co-Founder / strategic advisor

contact@vicinitybio.com

Scientific Work

Herold, N., Bruhns, M., Babaei, S., Spreuer, J., Castagna, A., Yurttas, C., Scheuermann, S., Seitz, C., Ruf, B., Konigsrainer, A., Jurmeister, P., Loffler, M. W., Claassen, M. and Wistuba-Hamprecht, K., High-dimensional in situ proteomics imaging to assess gammadelta T cells in spatial biology. J Leukoc Biol 2024. 115: 750-759.

Babaei, S., Christ, J., Sehra, V., Makky, A., Zidane, M., Wistuba-Hamprecht, K., Schurch, C. and Claassen, M., S(3)-CIMA: Supervised spatial single-cell image analysis for identifying disease-associated cell-type compositions in tissue. Patterns (N Y) 2023. 4: 100829.

Einhaus, J. et al. (2023) ‘High-multiplex tissue imaging in routine pathology—are we there yet?’, Virchows Archiv, 482(5), pp. 801–812. doi:10.1007/s00428-023-03509-6.

Aaron T. Mayer et al. ,A tissue atlas of ulcerative colitis revealing evidence of sex-dependent differences in disease-driving inflammatory cell types and resistance to TNF inhibitor therapy.Sci. Adv.9,eadd1166(2023).DOI:10.1126/sciadv.add1166

Tala Shekarian et al. , Immunotherapy of glioblastoma explants induces interferon-γ responses and spatial immune cell rearrangements in tumor center, but not periphery.Sci. Adv.8,eabn9440(2022).DOI:10.1126/sciadv.abn9440

Black, S., Phillips, D., Hickey, J.W. et al. CODEX multiplexed tissue imaging with DNA-conjugated antibodies. Nat Protoc 16, 3802–3835 (2021). https://doi.org/10.1038/s41596-021-00556-8

Phillips, D., Matusiak, M., Gutierrez, B.R. et al. Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma. Nat Commun 12, 6726 (2021). https://doi.org/10.1038/s41467-021-26974-6

Schürch, Christian M., et al. ‘Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front’. Cell, vol. 182, no. 5, Elsevier, Sept. 2020, pp. 1341-1359.e19, https://doi.org/10.1016/j.cell.2020.07.005.